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Comments (940)

  • Mr WordPress

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  • Pfizer

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    Sildenafil belongs to a bunch of chemicals referred to as phosphodiesterase
    inhibitors, that are answerable for dilating blood vessels and decreasing blood strain. Through the years, sildenafil and its compounds been used to enhance train means and lowering clinical illness development in patients with Pulmonary
    Arterial Hypertension (PAH).

    Normally marketed beneath a number of commerce names, Viagra as the commonest
    used to deal with erectile dysfunction, the oral
    formulation of sildenafil is a citrate salt of the compound Revatio (marketed by Pfizer).
    Identified chemically as 1-[[three-(6,7-dihydro-1-methyl-7-oxo-three-propyl-1H-pyrazolo [four,three-d] pyrimidin-5-yl)-four-ethoxyphenyl] sulfonyl]-four-methylpiperazine citrate,
    Revatio works by stopping the degradation of
    cyclic guanosine monophosphate (cGMP) within the
    lungs, which in flip releases the strain off the best aspect of the center, bettering blood-stream.

    How Revatio (Sildenafil citrate) Works

    Phosphodiesterase (PDE) comprise a gaggle of enzymes that together with the frequent PDE5
    which might be distributed evenly alongside the arterial
    partitions and easy muscle cells throughout
    the lungs. Sildenafil works by inhibiting cGMP-particular phosphodiesterase kind 5 (PDE5),
    which is chargeable for hydrolysis in cGMP. Revatio blocks
    the catalytic websites of PDE5, that are answerable for binding to cGMP, by binding itself to these websites.
    This prevents metabolic breakdown of cGMP and will increase
    its quantity within the blood, making certain regulation of calcium ion-channels
    and balancing calcium ranges within the cytosol.
    Ultimately, the method causes relaxation of the arterial muscles, discount of arterial stress, vasodilation and restoration of the conventional blood-move in and out of the guts.

    Revatio (Sildenafil citrate) Clinical Trials

    Revatio was first authorised by the FDA for remedy
    of patients with PAH in June 2005. Later, in November 2009, the FDA accepted Pfizer’s intravenous kind.
    The approvals adopted after a collection of profitable clinical trials with information suggesting the
    optimistic results of the drug on PAH patients in enhancing
    their exercising skills and slowing the speed of illness development.

    Nevertheless, in August 2012, the FDA dominated towards utilizing Revatio in kids.

    Dosage for Revatio ranges from 5mg to 20mg, relying on the patient’s situation and
    severity; 3 times each day, taken orally, a minimum of four-6 hours apart.
    If the affected person is unable to eat the drug orally,
    doses from 2.5mg to 10mg could be administered by way of the intravenous route; 3 times each day then presumably elevated per knowledgeable recommendation. Revatio might or is probably not used together with different vasodilators, however clinical trials haven’t decided any important enchancment when used
    together therapy. Patients with different ailments like coronary
    heart illness, renal or hepatic failure or bleeding disorders, ought to chorus
    from utilizing the drug with out knowledgeable opinion. Widespread antagonistic results for Rveatio embrace flushing, redness, irritation, headache, dizziness, muscle ache and stomach upsets.
    If extreme antagonistic results that inlcude allergic response, convulsions, listening to loss, or edema happen, a physician ought to be referred to
    as instantly.

    Note: Pulmonary Hypertension Information is strictly a information and data web site
    in regards to the illness. It doesn’t present medical recommendation, analysis or therapy.
    This content material is just not meant to be a substitute for skilled medical
    recommendation, analysis, or remedy. All the time search
    the recommendation of your physician or different certified well being supplier with any questions
    you might have concerning a medical situation. By no means disregard skilled
    medical recommendation or delay in looking for it due to one thing
    you may have learn on this webpage.

    Reply

  • Kathline Bivans

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    In a country where any mention of penis, phallus, that-thing-between-the-legs takes place only in the context of sexual innuendos and boastful size comparisons, it’s difficult for men to have an open conversation about Erectile Dysfunction.

    Reply

  • Juan Keiper

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    Erectile Dysfunction- Aggressive Landscape, Pipeline and Market Assessment, 2017, report delivers complete insights about marketed and pipeline medicine across this Mechanism of action. Crucial goal of the report is to build the comprehension for all the promoted and pipeline prescription drugs that tumble less than Erectile Dysfunction. This report gives info on the therapeutic improvement centered on Erectile Dysfunction system of motion working with around one hundred twenty+ active pipeline medications. Report handles the products scientific trials facts and other growth activities which include technology, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations information. Report incorporates the development and sale things to do for marketed medications. Delve Insight’s Report also assesses the Erectile Dysfunction therapeutics by Monotherapy, Combination goods, Molecule sort and Route of Administration. The report also handles the facts for 28+ energetic organizations included in the therapeutic progress of the merchandise

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  • David Minning

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    In a country where any mention of penis, phallus, that-thing-between-the-legs takes place only in the context of sexual innuendos and boastful size comparisons, it’s difficult for men to have an open conversation about Erectile Dysfunction.

    Reply

  • Esmeralda Kuebler

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    Extreme intake of liquor is a single of the most typical causes that lead to erectile dysfunction. Liquor is a depressant and lengthy phrase liquor consumption potential customers to ailments like hypertension. It influences the blood vessels which play a major part in erections through sexual encounters.

    Reply

  • Chaya Balangatan

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    Although hypertension and age older than 60 years were the only factors associated with diabetes-related ED in this study, longer diabetes duration, poor glycemic control, hyperlipidemia, sedentary lifestyle, smoking, and the presence of other diabetic complications have been noted in previous research. Patients should receive appropriate interventions related with these particular conditions, according to Dr Pizzol.

    Reply

  • Jamison Chais

    |

    Data suggests that ED is reported by 1 in every 5 men. Until recently, ED was thought to affect only older men but recent studies show that even younger men might have ED.

    Reply

  • Major Kolehmainen

    |

    According to the National Institutes of Health, only 4 percent of men in their 50s and 17 percent of men in their 60s experience total inability to have an erection. The percentage of complete ED increases from 5 percent to 15 percent as age increases from 40 to 70 years.

    Reply

  • Armando Faltz

    |

    Although hypertension and age older than 60 years were the only factors associated with diabetes-related ED in this study, longer diabetes duration, poor glycemic control, hyperlipidemia, sedentary lifestyle, smoking, and the presence of other diabetic complications have been noted in previous research. Patients should receive appropriate interventions related with these particular conditions, according to Dr Pizzol.

    Reply

  • Hollis Happney

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    In a country where any mention of penis, phallus, that-thing-between-the-legs takes place only in the context of sexual innuendos and boastful size comparisons, it’s difficult for men to have an open conversation about Erectile Dysfunction.

    Reply

  • Audry Olney

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    Erectile Dysfunction- Competitive Landscape, Pipeline and Industry Assessment, 2017, report delivers extensive insights about marketed and pipeline prescription drugs throughout this System of action. Key goal of the report is to create the understanding for all the promoted and pipeline medication that drop beneath Erectile Dysfunction. This report gives information on the therapeutic improvement based on Erectile Dysfunction system of action working with all around 120+ active pipeline prescription drugs. Report addresses the product or service medical trials data and other development pursuits which include technologies, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations facts. Report has the progress and sale routines for marketed medications. Delve Insight’s Report also assesses the Erectile Dysfunction therapeutics by Monotherapy, Mixture solutions, Molecule variety and Route of Administration. The report also covers the info for 28+ active providers included in the therapeutic improvement of the items

    Reply

  • Hui Chiodini

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    Advancements in QEQ scores with sildenafil vs placebo had been important (P<.0001) for the overall sample (33.7 sildenafil 8.1 placebo) and each age group (≤45 years: 38.5 sildenafil, 13.9 placebo 46-55 years: 34.9 sildenafil, 5.8 placebo ≥56 years: 26.9 sildenafil, 4.9 placebo). IIEF Erectile Function domain (P<.0001), question 3 (achieving erection P<.003), and question 4 (maintaining erection P<.001) scores also improved significantly for the overall sample and each age group. Treatment satisfaction was significantly greater (P<.0001) with sildenafil vs placebo for the overall sample and each age group. The most common AEs with sildenafil were headache, flushing and nasal congestion in all age groups.

    Reply

  • Darrick Limke

    |

    Stress is a major cause of ED, especially in young adults. In many cases, they aren’t able to perform due to unrealistic expectations. Even lifestyle issues like smoking, excessive drinking and drug abuse can cause ED.

    Reply

  • Noelia Darius

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    Abnormal usage of liquor is one of the most frequent triggers that lead to erectile dysfunction. Liquor is a depressant and extensive expression alcohol intake sales opportunities to ailments like hypertension. It influences the blood vessels which enjoy a key function in erections through sexual encounters.

    Reply

  • Kermit Landy

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    The report provides aggressive pipeline landscape of Erectile Dysfunction. The report delivers the promoted medications information and facts which includes its product sales, growth activities and aspects of patent expiry. The report provides the perception of recent and future sector for Erectile Dysfunction. The report delivers pipeline products beneath drug profile area which consists of product or service description, MOA, licensors & collaborators, progress partner and chemical information and facts. Coverage of the Erectile Dysfunction pipeline on the foundation of goal, MOA, route of administration, technology concerned and molecule form. The report critiques key gamers associated in the therapeutics improvement for Erectile Dysfunction and also present business profiling. The report also provides the information of dormant pipeline initiatives. Pipeline goods coverage based mostly on several levels of growth ranging from preregistration till discovery and undisclosed stages and Gives pipeline assessment by monotherapy and mixture therapy solutions, phase of enhancement and molecule sort.

    Reply

  • Nestor Hillerman

    |

    As per WedMD, ‘other conditions that may cause ED include cardiovascular disease, atherosclerosis (hardening of the arteries), kidney disease, and multiple sclerosis. These illnesses can impair blood flow or nerve impulses throughout the body’.

    Reply

  • Val Bonsal

    |

    “Considering the association between depressive symptoms and erectile dysfunction, especially in diabetic patients, management should be multidisciplinary,” Dr Pizzol added. “In addition to the skills and expertise of the metabolic diseases specialist and traditional pharmacological therapy, psychosexual counseling and specialist andrologist/urologist advice is necessary.”

    Reply

  • Jamal Capdeville

    |

    Illnesses involved with the coronary heart or blood vessels are termed cardiovascular diseases. Stroke, coronary heart failure, heart arrhythmia are cardiovascular ailments and they may perhaps result in erectile dysfunction. Cardiovascular ailments are brought about by quite a few elements including superior blood cholesterol, diabetic issues and other such ailments. The very best way to stay away from these types of illnesses is nutritious way of living alternatives and exercising.

    Reply

  • Frederic Stasulis

    |

    Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

    Reply

  • Nyla Franzoni

    |

    “Considering the association between depressive symptoms and erectile dysfunction, especially in diabetic patients, management should be multidisciplinary,” Dr Pizzol added. “In addition to the skills and expertise of the metabolic diseases specialist and traditional pharmacological therapy, psychosexual counseling and specialist andrologist/urologist advice is necessary.”

    Reply

  • Stan Belli

    |

    Abnormal use of alcoholic beverages is 1 of the most frequent causes that direct to erectile dysfunction. Alcoholic beverages is a depressant and long expression alcoholic beverages consumption sales opportunities to conditions like hypertension. It impacts the blood vessels which participate in a major purpose in erections in the course of sexual encounters.

    Reply

  • Huey Kuechler

    |

    The purpose of this analyze was to evaluate erection top quality with sildenafil vs placebo and adverse gatherings (AEs) according to age (≤45, forty six-55 and ≥56 many years) in 997 adult men with erectile dysfunction (ED) applying pooled info from 4 randomized, double-blind, placebo-controlled, flexible-dose trials.

    Reply

  • Nicky Swanteck

    |

    “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

    Reply

  • Bernetta Cervera

    |

    Illnesses affiliated with the coronary heart or blood vessels are termed cardiovascular illnesses. Stroke, heart failure, heart arrhythmia are cardiovascular conditions and they may well final result in erectile dysfunction. Cardiovascular conditions are triggered by numerous variables like large blood cholesterol, diabetic issues and other this sort of situations. The best way to keep away from this kind of disorders is healthful way of living possibilities and physical exercise.

    Reply

  • Chadwick Deichman

    |

    Sildenafil significantly improved erection quality across all age groups of men with ED. Efficacy improvements with sildenafil were consistent with the QEQ, IIEF, and EDITS. AEs were comparable across age groups. ClinicalTrials.gov ID: NCT00159900, NCT00147628, NCT00301262, NCT00343200.

    Reply

  • Kyle Galofaro

    |

    Improvements in QEQ scores with sildenafil vs placebo have been important (P<.0001) for the overall sample (33.7 sildenafil 8.1 placebo) and each age group (≤45 years: 38.5 sildenafil, 13.9 placebo 46-55 years: 34.9 sildenafil, 5.8 placebo ≥56 years: 26.9 sildenafil, 4.9 placebo). IIEF Erectile Function domain (P<.0001), question 3 (achieving erection P<.003), and question 4 (maintaining erection P<.001) scores also improved significantly for the overall sample and each age group. Treatment satisfaction was significantly greater (P<.0001) with sildenafil vs placebo for the overall sample and each age group. The most common AEs with sildenafil were headache, flushing and nasal congestion in all age groups.

    Reply

  • Marlin Kennaugh

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    A high-profile clinic that targets men with erectile dysfunction has been charged with misleading advertising and creating false expectations among its customers.

    Reply

  • Sonny Ripa

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    Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

    Reply

  • Nikita Wettach

    |

    “Considering the association between depressive symptoms and erectile dysfunction, especially in diabetic patients, management should be multidisciplinary,” Dr Pizzol added. “In addition to the skills and expertise of the metabolic diseases specialist and traditional pharmacological therapy, psychosexual counseling and specialist andrologist/urologist advice is necessary.”

    Reply

  • Sharika Balter

    |

    Medication have an impact on your nervous technique and some even block your testosterone causing erectile dysfunctions. Using tobacco impacts your blood vessels and success in blockage of arterial blood provide to the penis consequently primary to erectile dysfunction. Expressing no to medication and smoking cigarettes is indirectly expressing indeed to sex.

    Reply

  • Marianne Luma

    |

    The intention of this examine was to assess erection good quality with sildenafil vs placebo and adverse gatherings (AEs) in accordance to age (≤45, 46-fifty five and ≥56 decades) in 997 gentlemen with erectile dysfunction (ED) working with pooled details from four randomized, double-blind, placebo-controlled, flexible-dose trials.

    Reply

  • Darell Halvorson

    |

    Medicine have an impact on your nervous process and some even block your testosterone producing erectile dysfunctions. Smoking cigarettes affects your blood vessels and effects in blockage of arterial blood provide to the penis as a result top to erectile dysfunction. Declaring no to medication and using tobacco is indirectly declaring certainly to sex.

    Reply

  • Izola Fuscaldo

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    More than half of men with diabetes have erectile dysfunction (ED), according to a new meta-analysis of international studies.

    Reply

  • Francis Monterroza

    |

    The trials incorporated 6- to 10-7 days procedure intervals. The starting up sildenafil dose was fifty mg, taken ~1 hour ahead of sexual activity but not extra than as soon as daily, with subsequent adjustment to one hundred or twenty five mg based on efficacy and basic safety. Exclusion requirements provided blood pressure one hundred seventy/a hundred and ten mmHg, taking nitrate therapy or nitric oxide donors, significant cardiac failure/unstable angina or new stroke or myocardial infarction. Improvements from baseline in Top quality of Erection Questionnaire (QEQ), Global Index of Erectile Functionality (IIEF) and Erectile Dysfunction Inventory of Treatment Gratification (EDITS) scores were analysed.

    Reply

  • Rudolph Stickney

    |

    The goal of this review was to evaluate erection excellent with sildenafil vs placebo and adverse gatherings (AEs) in accordance to age (≤45, forty six-fifty five and ≥56 several years) in 997 adult men with erectile dysfunction (ED) working with pooled facts from four randomized, double-blind, placebo-managed, flexible-dose trials.

    Reply

  • Bernie Ciano

    |

    The report delivers aggressive pipeline landscape of Erectile Dysfunction. The report delivers the marketed medications information and facts which includes its gross sales, development things to do and aspects of patent expiry. The report gives the perception of present and future market place for Erectile Dysfunction. The report gives pipeline products below drug profile segment which involves merchandise description, MOA, licensors & collaborators, development lover and chemical details. Protection of the Erectile Dysfunction pipeline on the basis of target, MOA, route of administration, technological know-how involved and molecule form. The report critiques crucial gamers associated in the therapeutics growth for Erectile Dysfunction and also offer organization profiling. The report also presents the info of dormant pipeline assignments. Pipeline products coverage dependent on several phases of improvement ranging from preregistration till discovery and undisclosed levels and Supplies pipeline assessment by monotherapy and combination treatment merchandise, phase of advancement and molecule type.

    Reply

  • Oda Partida

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    In a country where any mention of penis, phallus, that-thing-between-the-legs takes place only in the context of sexual innuendos and boastful size comparisons, it’s difficult for men to have an open conversation about Erectile Dysfunction.

    Reply

  • Laurene Pinckley

    |

    “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

    Reply

  • Isaias Stollar

    |

    Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

    Reply

  • Terrance Sartell

    |

    More than half of men with diabetes have erectile dysfunction (ED), according to a new meta-analysis of international studies.

    Reply

  • Guy Lookabaugh

    |

    Medication have an affect on your anxious technique and some even block your testosterone producing erectile dysfunctions. Smoking cigarettes affects your blood vessels and final results in blockage of arterial blood provide to the penis hence top to erectile dysfunction. Indicating no to medication and smoking cigarettes is indirectly declaring yes to sexual intercourse.

    Reply

  • Lesia Jacocks

    |

    Improvements in QEQ scores with sildenafil vs placebo were being substantial (P<.0001) for the overall sample (33.7 sildenafil 8.1 placebo) and each age group (≤45 years: 38.5 sildenafil, 13.9 placebo 46-55 years: 34.9 sildenafil, 5.8 placebo ≥56 years: 26.9 sildenafil, 4.9 placebo). IIEF Erectile Function domain (P<.0001), question 3 (achieving erection P<.003), and question 4 (maintaining erection P<.001) scores also improved significantly for the overall sample and each age group. Treatment satisfaction was significantly greater (P<.0001) with sildenafil vs placebo for the overall sample and each age group. The most common AEs with sildenafil were headache, flushing and nasal congestion in all age groups.

    Reply

  • Alvina Demars

    |

    As per WedMD, ‘other conditions that may cause ED include cardiovascular disease, atherosclerosis (hardening of the arteries), kidney disease, and multiple sclerosis. These illnesses can impair blood flow or nerve impulses throughout the body’.

    Reply

  • Alease Arra

    |

    Although hypertension and age older than 60 years were the only factors associated with diabetes-related ED in this study, longer diabetes duration, poor glycemic control, hyperlipidemia, sedentary lifestyle, smoking, and the presence of other diabetic complications have been noted in previous research. Patients should receive appropriate interventions related with these particular conditions, according to Dr Pizzol.

    Reply

  • Laura Mcleary

    |

    And then there is old age. It has been observed that erectile dysfunction is widespread among the adult men more mature than 50 many years of age. Nonetheless, irrespective of age, erectile dysfunction can be taken care of.Most of these results in can be prevented by using good care of your health and fitness. Nonetheless, if you do conclude up going through the symptoms of erectile dysfunction, you need to seek advice from a medical doctor and get your self taken care of to appreciate a satisfied and satisfying sexual life.

    Reply

  • Marcus Wiren

    |

    “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

    Reply

  • Harold Mortier

    |

    Health conditions associated with the heart or blood vessels are known as cardiovascular illnesses. Stroke, coronary heart failure, coronary heart arrhythmia are cardiovascular conditions and they might end result in erectile dysfunction. Cardiovascular conditions are brought on by several elements like significant blood cholesterol, diabetes and other this kind of circumstances. The greatest way to avoid this sort of conditions is healthful life style alternatives and exercising.

    Reply

  • Carroll Geathers

    |

    More than half of men with diabetes have erectile dysfunction (ED), according to a new meta-analysis of international studies.

    Reply

  • Elijah Milford

    |

    The trials included 6- to 10-week treatment intervals. The starting up sildenafil dose was fifty mg, taken ~1 hour prior to sexual exercise but not much more than after daily, with subsequent adjustment to a hundred or 25 mg primarily based on efficacy and basic safety. Exclusion standards integrated blood pressure a hundred and seventy/one hundred ten mmHg, getting nitrate remedy or nitric oxide donors, significant cardiac failure/unstable angina or recent stroke or myocardial infarction. Changes from baseline in High quality of Erection Questionnaire (QEQ), Intercontinental Index of Erectile Operate (IIEF) and Erectile Dysfunction Inventory of Procedure Satisfaction (EDITS) scores had been analysed.

    Reply

  • Richard Krumrine

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    More than half of men with diabetes have erectile dysfunction (ED), according to a new meta-analysis of international studies.

    Reply

  • Jacque Galofaro

    |

    Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

    Reply

  • Tammara Toban

    |

    According to the National Institutes of Health, only 4 percent of men in their 50s and 17 percent of men in their 60s experience total inability to have an erection. The percentage of complete ED increases from 5 percent to 15 percent as age increases from 40 to 70 years.

    Reply

  • Dwight Gelo

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    Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

    Reply

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